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Frank's sign or Frank sign is a diagonal ear lobe crease (ELC) extending diagonally from the tragus across the lobule to the rear edge of the auricle. The sign is named after Dr. Sanders T. Frank. It has been hypothesised that Frank's sign is indicative of cardiovascular disease〔Miot, H.A., Molina de Medeiros, M. etal (2006). (Association between coronary artery disease and the diagonal earlobe an preauricular creases in men. ) Anais Brasileiros de Dermatologia. vol.81 no.1〕 and/or diabetes. Some studies have described Frank's sign as a marker of cardiovascular disease but not linked to the severity of the condition. In contrast, other studies have rebutted any association between Frank's sign and coronary artery disease in diabetics. There have also been reported cases of Frank's sign assisting in the diagnosis of cerebral infarctions. A link between Frank's sign and premature aging and the loss of dermal and vascular fibers has also been hypothesized. However, researchers do agree that these creases have no predictive value in Native American Indian and Asian patients. Some studies have focused upon bilateral ELC. ==Severity== *Grade 3 - A deep crease across the whole of the earlobe *Grade 2a - Creased more than halfway across the earlobe *Grade 2b - A superficial crease across the earlobe *Grade 1 - A small amount of wrinkling on the earlobe 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Frank's sign」の詳細全文を読む スポンサード リンク
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